The Portuguese’s early strike in Cologne came from United’s 22nd penalty of the season
Portugal midfielder Fernandes blasted his spot-kick beyond Sevilla goalkeeper Bono into the top corner to put the Red Devils ahead just nine minutes in after Marcus Rashford had been fouled by defender Diego Carlos.
Rashford had managed to get in a shot on goal before he was brought down, but referee Felix Brych still pointed to the spot.
It was the 22nd penalty United have won in all competitions this season, the most a team has had in Europe’s top five leagues since Barcelona won 24 in 2014-15.
Ultimately, however, the penalty from Fernandes wasn’t enough on the night as Sevilla turned around the early deficit to advance past United with a 2-1 win.
Fernandes has certainly benefited from United winning so many penalties. He has scored a remarkable 12 goals for the Red Devils since his €55 million (£47m/$60m) move from Sporting during the January transfer window, with eight of those coming from the penalty spot.
That includes the only goal in extra-time of the Europa League quarter-final against FC Copenhagen on Monday, as well as the opener in their crucial final Premier League match of the season against Leicester, with their eventual 2-0 win securing qualification for next season’s Champions League.
The 25-year-old’s influence extends beyond just penalties, though. Fernandes has eight assists to his name in a United shirt, meaning only Bayern Munich’s Robert Lewandowski and Barcelona superstar Lionel Messi have had a hand in more goals in all competitions since Fernandes made his debut against Wolves at the start of February.
Despite making a flying start in Cologne, United were unable to hold on to the lead given to them by Fernandes.
Sevilla were level on 26 minutes when Sergio Reguilon’s cross from the left found former Liverpool player Suso, who swept the ball beyond David de Gea. Substitute Luuk de Jong then scored the winner with 12 minutes remaining.